bPanel offers several ways to interact directly with the Bitcoin Blockchain through bcoin. All functionality that is available through the bcoin API (which supports: RPC, WebSockets, and REST) can be accesed in bPanel plugins.
Whether you want to manage wallets, get node information, blacklist peers, even mining operations, if it's available in bcoin, you can build a plugin that interacts with the interface.
The Node Info guide has working examples of working with sockets and the REST API.
Check out the full bcoin API documentation for more information on what is available.